Heme oxygenase-1 (HO-1), a kind of antioxidative enzymes, was the rate-limiting enzyme of heme degradation which produces bilirubin, carbon monoxide(CO), and iron.

• 血红素加氧合酶-1(HO-1)是一种最广泛存在的抗氧化防御酶，是热体克蛋白家族中的一个成员，可代谢血红素生成CO、胆红素和游离铁；