Glickman says social ecology and genetics may also play a role in trial outcomes, and may limit their applicability to patients who do not share such characteristics.

• 另一个问题是在海外开展临床研究获批的药物是否在研究的开展国家以合理的价格销售。另外，在海外开展的临床研究，评价的药物是否是该国所需要的？