Full-length Cubilin is composed of 3623aa (molecular weight, 460kD), involving 8 EGF-like domains at N-terminal and 27 CUB domains. The CUB domains are also the main functional domains, responsible for binding to most of ligands.

• Cubilin全长3623aa,460kD,由N-端,8个EGF样结构和27个CUB结构域组成[12],CUB结构域是主要的功能域,负责和绝大部分的配体结合,其中CUB7-8结构域是白蛋白的结合域,但二者结合的关键氨基酸残基尚未确定[13]。