Fluorosis is the major concern of long term fluoride supplementation, however it could be prevented by limiting the starting age from 3 years or older.

• 长期使用氟锭虽可能造成氟斑牙，但已有国外报告建议3岁以上孩童使用氟锭，可避免氟离子于牙齿发育期之影响，减少氟斑牙发生。