Fang and Sass et al demonstrated hepatic HMGB1 concentration were remarkably increased in system sepsis and endotoxemia, we propose a key link between liver up-regulated HMGB1 and acute liver injury(ALI).

• 这些因素均是诱导HMGB1表达释放的重要因素。 为此,我们推测在急性肝损伤时,肝内HMGB1的释放也会增多和介导肝损伤甚至肝衰竭。