Electrochemical detection of DNA hybridization usually involves monitoringof a current response, resulting from the Watson-Crick base pair recognition event, under controlled potential conditions.

• 将电化学活性良好的纳米金、银以及壳一核型合金纳米微粒，分别标记在疏基修饰的寡聚核昔酸片段上，制备成金属纳米微粒标记DNA电化学探针，通过与固定在电极表面的互补靶DNA杂交后，检测探针上标记物的电化学信号来识别和测定靶序列。