ET-lmRNA was overexpressed in arota of DHR, and increased ET-1 can result in vascular smooth muscle cell hypertrophy and mitogenesis through ETA and ETB receptors.

• DHR主动脉组织中ET一1mRNA表达增多，ET一1合成增加，ET一1作用于VSMC上的ETA、ETB型受体，引起VSMC增生、肥大，导致主动脉中层增厚。