EPF has been identified as an extracellular homologue of HSP10 since its amino acid sequence and molecular weight are similar to HSP10. (2) Heat shock protein 60 (HSP60) .

• HSP60：它与HSP10都属线粒体蛋白，两者的基因定位在同一条染色体的相同位点上，在结构和功能上紧密相关。 已有大量文献报道HSP60与肺癌、大肠癌、乳腺癌、卵巢癌等多种恶性肿瘤关系密切。