During the period of Anti-Japanese War, the overseas market was disrupted; except few Coptis sold overseas via Guangzhou, most Coptis sold inside the country such as Hankou, Tianjin, Jinan etc.

• 抗日战争时期，国际销路中断，除一部分黄连由广州出国外，大都内销汉口、天津、济南等地。