Dosing intervals for drugs that are excreted by the kidney, such as aminoglycoside antibiotics, digoxin and pancuronium need to be adjusted and drug levels closely monitored.

• 对于通过肾脏排泄的药物（如:氨基糖甙类抗生素、地高辛、蟠龙等）给药间隔须调整并且严密监测药物水平。