Dihydropyridine calcium channel blockers used alone may cause problems for patients with chronic renal disease by tending to increase proteinuria.However, an ACE inhibitor will blunt this effect.

• 二氢核黄素钙通道阻滞剂如果针对慢性肾病的人单独使用会引起尿内蛋白升高的问题，不过，如果配用血管紧缩素转化酶抑制剂会降低这种副作用。