Despite the monogenetic origin of familial hypercholesterolemia, the incidence of coronary heart disease varies considerably among patients, which is only partly explained by classical risk factors.

• 冠心病发病率的个体差异相当大可能与几项经典危险因子相关。其中高血压是与血管紧张素原水平相关的冠心病的重要危险因子。