Data from this study indicate that the inhibition of p15INK4B and p21WAF1/cip1 may be one of the mechanisms by which HDAC3 participates in cell cycle regulation and oncogenesis.

• 干涉质粒能诱导p15INK4B基因表达活性的升高，而对p21WAF1/cip1的表达没有什么影响。本研究表明去乙酰化酶3可能是通过抑制p15INK4B和p21WAF1/cip1这种方式来参与周期调控和癌症发生的。