CpG islands of PRA and PRB promoters were demethylated and PRAB and PRBmRNA were re-expressed after 5-Aza CdR treatment.

• 5-Aza CdR处理L-60、K562、Jurkat后，PRA、PRB启动子CpG岛发生去甲基化，PRAB、PRB mRNA恢复表达。