Conclusions The results suggested that VEGF-C may be a factor of lymphatic metastasis of laryngeal cancer, and it is possible to be used as a predictor of lmphatic metastasis of laryngeal cancer.

• 结论喉癌细胞分泌VEGF-C诱导癌内和癌周淋巴管增生扩张是喉癌发生颈淋巴结转移的重要因素之一，VEGF-C检测有望作为临床早期判断和预测颈淋巴结转移的指标之一。