Conclusion: The treatment of valsartan plays an important role in protecting the endothelial function through inhibiting endothelin excreting ET and promoting endothelin excreting NO.

• 结论: 缬沙坦通过促进内皮细胞分泌NO，抑制内皮细胞分泌内皮素，对肾性高血压大鼠血管内皮细胞功能具有保护作用。