Conclusion: Irbesartan can up-regulate the renal HGF, strengthen its renotrophic function and retard the development of glomerular sclerosis and tubulointerstitial fibrosis.

• 结论：厄贝沙坦可以上调肾组织HGF的分泌，加强HGF的肾保护作用，延缓肾小球硬化，减轻肾小管-间质纤维化。