Conclusion The low expression of DPC4 gene can be an early event during lung carcinogenesis.Simultaneously, it promoted lymph node metastasis.The high expression of DPC4 may promote the cell apotosis.

• 结论DPC4的低表达可能是肺癌发生过程的早期事件，可促进肺癌的淋巴结转移，DPC4的高表达可能促进细胞的凋亡。