Conclusion PTEN gene plays an important role in carcinogenesis and progress of gastric cardia carcinoma.Expression of PTEN may prove to be valuable in prognosis assessment of gastric cardia carcinoma.

• 结论从蛋白水平证明PTEN基因表达缺失或降低与贲门癌的发生发展有关，PTEN蛋白表达的检测可能成为判断贵门癌细胞生物学行为及部分患者预后的参考指标之一。