Conclusion Our data suggest that long-term administration of TW has remarkable effect on skeletal system in SLE patients, and increases the risk rate of osteoporosis and bone fracture.

• 结论长期服用雷公藤对系统性红斑狼疮患者骨骼系统有显著影响，使之以后发生骨质疏松和骨折的危险度增加，应引起临床医师的重视。