Conclusion LC noradrenergic neurons are overactive and more irregular in 6-OHDA-lesioned rats.These changes suggest an implication of the LC in the pathophysiological mechanism of PD.

• 结论 6-羟多巴胺损毁术后，大鼠蓝斑核肾上腺素能神经元活动增强，且更不规则，提示蓝斑核参与帕金森病的发病。