Conclu- sion Upregulating PKA activity can significantly decrease cell viability of T24 cells,and can lead to re- duction of cyclin D1 expression,resulting in G_1 arrest and proliferation inhibition.

• 结论forskolin能够显著上调T24细胞中PKA的活性,PKA活性增高使T24细胞处于G_1期静止,抑制其增殖,并显著降低细胞活力。 PKA活性增高所致的G_1期静止可能与Cyclin D1的表达下降有关。