CONCLUSION: Nickel ion seems to be released from the occluder, causing a systemic rise in serum levels of nickel.Endothelialization of the device surface inhibits nickel release.

• 结论：镍离子可以从封堵器表面释放导致血循环引起血浆镍含量升高，而封堵材料表面内皮化的形成阻碍镍离子的进一步释放。