CFC syndrome can be distinguished from CS by the rare presence of papillomata, fetal pads, acanthosis nigricans, wrinkled palms and soles, and loose skin of the hands and feet.

• 而心脏-脸-皮肤徵候群患者罕见乳突瘤，胎儿垫，黑棘皮病，手掌脚掌皱纹及手脚疏松的皮肤，这些可以和科斯特洛徵候群区别。