By analysing the metabolite variations in rats that had suffered a strong toxic reaction to the drug, compared to those that were unaffected, Nicholson was able to draw up a risk profile for rats.

• 通过比较分析由于药物而备受煎熬的老鼠和未受药物影响的老鼠他们所分泌的代谢物变化，尼科尔森能大致为这些老鼠做一个风险因素蓝图。