But those who refilled their Actos or Avandia prescriptions eight times or more -- about 12 to 18 months of use -- had nearly twice the fracture risk of other patients.

• 但那些连续8次以上处方服用艾可拓或文迪雅，也就是服用12到18个月的患者，比起其他的患者骨折的危险性要高近一倍。