But because of the toxicity of the local anesthetic, especially long effect of local anesthetic bupivacaine as the representation with strong toxicity,so application are restrict in clinic.

• 但由于局麻药的毒性问题,特别是以布比卡因为代表的长效局麻药毒性较强,因此在临床麻醉中的应用受到限制。