Bup could inhibit the abstinence syndrome effectively; the level of the pituitary glands POMC-mRNA dropped both in morphine dependent rats and abstinence rats, which was slightly influenced by Bup.

• ··:丁丙诺啡能有效减轻或消除戒断体征,吗啡依赖及戒断时大鼠垂体POMC -mRNA含量下降,丁丙诺啡对其影响不大。