Based on the structure-activity studies of the leading compounds, we designed and synthesized a new series of ET receptor antagonists with different N-terminal chemical groups and unnatural amino acids.

• 基于先导化合物自身的结构特征，参考文献提供的构效关系研究信息，通过改变N-端结构、引入非天然氨基酸或非氨基酸等方法，设计合成了一系列新结构类型的肽类内皮素受体拮抗剂。