Background:The chronic inflammation and necrosis of liver parenchyma caused by any kind of pathogeny can arouse durative hyperplasia of fibril connective tissue, once the hyperplasia exceeds the degradation liver fibrosis will occur.

• 背景各种病因所致的慢性肝实质炎症、坏死可引起持续性纤维结缔组织增生,一旦超过纤维的降解即可导致肝脏纤维化,弥漫性肝纤维化同时伴有肝小叶结构的被破坏和肝再生结节则形成肝硬化。