Antitumor agent tirapazamine was synthesized from o-nitroaniline by oxidation to give benzofuroxanwhich reacted with sodium cyanamide followed by acid hydrolysis with an overall yield of 75%.

• 邻硝基苯胺经氧化得到苯并呋咱1-氧化物,与氰氨基钠反应后酸解得到抗癌剂替拉扎明,总收率75%25。