An intermediate of bone resorption inhibitor risedronate sodium,3 pyridine acetic acid hydrochloride, was synthesized from ethyl nicotinate via reduction, chlorination, cyanation and hydrolysis.

• 以烟酸乙酯为原料,经还原、氯代、氰化、水解等反应合成了骨吸收抑制剂利塞膦酸钠中间体3-吡啶乙酸盐酸盐。