An HPLC method was established for the determination of indirubin to study the solubilities of the solid system with indirubin as a reference substance.

• 结果共研磨技术和共沉淀法有效提高了靛玉红的表观溶解度,不同载体研究表明共研物中亲水载体的羟基对改善难溶性药物的溶解度有着重要的影响。