Alterations in horaeostasis after various cellular stresses, which prevent protein folding and cause accumulation of misfolding proteins in the ER, have the potential to induce cellular damage.

• 各种应激不但可以破坏机体的内环境，还可以抑制蛋白质的正确折叠，引起错误和不完全折叠的蛋白质聚集于内质网，并对细胞和组织造成伤害。