After treatment of MNC of CML and K562 with imatinib in vitro, the expression of DNA-PKcs protein was enhanced while tyrosine phosphorylation of bcr-abl fusion protein decreased.

• 伊马替尼体外作用于CML患者MNC及K562细胞后,DNA-PKcs蛋白表达量随着bcr-abl融合蛋白酪氨酸磷酸化水平的降低而升高。