After cloning the FUT2 gene by Kelly et al,molecular analyses of FUT2 indicated the non-function alleles (se) which were generated by single base mutation (G428A A385T C57IT C628T,G849A and C658T) caused Se enzyme deficient.

• 1995年Kelly等克隆了FUT2基因后，对FUT2基因的分子分析指出，该基因蛋白编码区内单个碱基的突变(G428A，A385T，C571T，C628T，G849A，C658T)产生的无功能等位基因(se)导致Se酶活性丧失。