After a one-week wash out period, the volunteers of 400 mg group participated in the multiple dose design in which each volunteer received 400 mg fudosteine three times a day for five consecutive days.

• 中剂量组受试者单次口服福多司坦400 mg后,经过1周清洗期,再每日3次,每次400 mg,连续服药5 d。