Accumulation of cells in S+G 2/M phase of the cell cycle was observed in the cells treated with VP16 and Z-LLL-CHO alone, while apparent increase of s ub-G 0/G 1 fraction was detected in cells treated with combination of the agents.

• 流式细胞术检测提示单独应用Z LLL CHO及VP16均可使S +G2 /M期细胞比例增加 ,两者联合应用导致细胞凋亡峰比例的显著增高。