AIM To explore the molecular changes in genes p15 INK4b and p16 INK4a associated with cyclophosphamide(CP) and thiotepa(TEPA) mediated carcinogenesis.

• 目的 了解环磷酰胺 (CP)和塞替哌 (TEPA)诱导永生化人支气管上皮细胞 (BEAS 2B)的恶性转化株内BEAS CP和BEAS TE细胞p16和p15基因的突变情况。