A single-chain bispecific antibody COC183B2/anti-CD3 is constructed and expressed successfully, which can keep approximately the antigen-binding affinity of the two parent ScFvs.

• 构建和表达抗人卵巢癌COC183B2 /抗CD3scBsAb成功 ,且具有与抗原OC183B2、CD3结合的免疫学活性