A new process has been developed to synthesize dimethoxy methylaceto acetate from dimethoxyacetic methyl acetate and methyl acetate in the presence of sodium methanol as catalysis.

• 以二甲氧基乙酸甲酯和乙酸甲酯为主要原料,经甲醇钠催化,制备药物尼伐地平中间体二甲氧基乙酰乙酸甲酯。