4 Chloro 4,5 dimethyl 1,3 dioxolan 2 one was synthesized from 3 hydroxy 2 butanone by acylation and cyclization, the yield was above 86%.

• 以羟基丁酮为原料,经酰化、环合等步骤合成医药中间体4氯4,5二甲基1,3二氧杂环戊烷2酮,合成收率达86%25以上