这种持续的盲目乐观，首先是由于没有认识到，肿瘤从它的基因组不稳定性所获得的的巨大能力，能够利用自然选择战胜要毁坏它的内部的和治疗的尝试。

• This sustained overoptimism has, above all, been due to a widespread failure to appreciate the enormity of the power that a tumour obtains from its genomic instability and consequent ability to exploit natural selection to outflank both endogenous and therapeutic attempts to destroy it.